[Drugs for hydrocephalus]_How to treat_How to use medicine
There are many liquid substances in our brain. When these secretions in our brain are not quickly absorbed by the circulation, it will cause too much water in the brain.
Dehydration drugs, hormonal drugs, and diuretics are all typical drugs for treating hydrocephalus. Their role is mainly to reduce the secretion of cerebrospinal fluid and promote the absorption of cerebrospinal fluid to achieve the purpose of inhibiting the secretion of cerebrospinal fluid, and finally treat the brainStanding water.
The drugs used to treat hydrocephalus include: 1. Dehydration drugs: typical representative drug mannitol, which can quickly lower the intracranial pressure, reduce the secretion of cerebrospinal fluid, and achieve the effect of relieving hydrocephalus; 2. hormone drugs: reduce the secretion of cerebrospinal fluid, promoteCerebrospinal fluid absorption and better brain protection; 3, diuretics: reduce water volume, reduce cerebrospinal fluid secretion, to achieve the effect of treating hydrocephalus; 4, carbon metabolic enzyme inhibitors: typical representative drug acetazolamide,Inhibit cerebrospinal fluid secretion.
Hydrocephalus is an alternative to cerebrospinal fluid secretion due to craniocerebral disorders resulting in excessive secretion or (and) circulation and increased absorption of intracranial cerebrospinal fluid due to malabsorption, causing expansion of the ventricular system or (and) subarachnoid space.
Its typical symptoms are headache, vomiting, blurred vision, edema of the optic nerve head, occasional diplopia, dizziness, and seizures.
Although 20% of untreated congenital hydrocephalus can stop developing, about half of the children die within a year and a half.
Neurological dysfunction in patients with hydrocephalus is positively related to the severity of hydrocephalus and should be actively diagnosed and treated.
After the formation of hydrocephalus, the cerebrospinal fluid circulation path is blocked and causes secondary changes in the brain tissue: it is manifested by the expansion of the ventricular system due to the accumulation of cerebrospinal fluid, which is stretched through the ventricle wall, the ventricular membrane gradually disappears, and the ventricle is roundCellular or glial scar formation.
The ventricle further expands, causing the cerebrospinal fluid to enter the periventricular tissue and cause white matter edema. At this time, the cerebrospinal fluid shunt operation is performed to restore the ventricle to normal size, and the histological changes of the brain tissue cannot be recovered.
If hydrocephalus develops further and the cerebral cortex becomes thinner, secondary brain atrophy may occur.
The expansion of the third ventricle adapts to the compression of the hypothalamus and atrophy, and the compression of the midbrain makes the vertical movement of the eyeball obstructed, and the “sunset sign” seen in the clinic appears.
Increased intracranial pressure caused by hydrocephalus is transformed into bilateral transverse sinus compression, which impedes blood flow into the jugular internal jugular vein, thereby increasing the blood circulation of the modern reimbursable external jugular vein system and secondary scalp vein angerZhang.